International Journal of Herbal Medicine
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E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20 NAAS Rating: 3.20
International Journal of Herbal Medicine
Vol. 2, Issue 1, Part A (2014)

Lonicera japonica alters antigen-stimulated T cell functions.

Author(s): Austin Brooks, Jessica Jonkman, Zach Bookmyer, Heather A. Bruns
Abstract: Lonicera japonica is a honeysuckle species commonly used in traditional Chinese medicine, having a variety of anti-inflammatory and immune-enhancing properties.  Studies examining individual constituents of L. japonica as well as concoctions containing L. japonica have demonstrated that it inhibits the proliferation of stimulated T cells, potentially contradicting the immune-enhancing function of L. japonica.  This study investigated the effect of L. japonica dried herb extract (1:5) on T cell function in vitro to elucidate the comprehensive effect of L. japonica on T cell-mediated immune function.  Purified murine T cells were stimulated in the presence or absence of L. japonica, and alterations in protein expression, proliferation, and cell survival of T cells were assessed. L. japonica inhibited proliferation, altered protein expression, and increased the death of antigen-stimulated T lymphocytes, suggesting that L. japonica may serve a role in regulating T cell function, but may contribute to the generation of an ineffective immune response if used inappropriately.
Pages: 13-20  |  912 Views  11 Downloads
How to cite this article:
Austin Brooks, Jessica Jonkman, Zach Bookmyer, Heather A. Bruns. Lonicera japonica alters antigen-stimulated T cell functions.. International Journal of Herbal Medicine. 2014; 2(1): 13-20.
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