Author(s): Hardik Soni, Sweta Patel, Arindam Paul, Ghanshyam Patel

Abstract: Stress is an adaptive physiological response to disruption of homeostasis. Stress-induced gastric ulceration is a typical example of stress-associated organ injuries. The present study was carried out to evaluate gastroprotective effect of Pep-Up Tablet and Syrup, proprietary Ayurvedic formulations, on water immersion plus restraint stress-induced gastric ulcer in rats. Both test drugs were studied for their effect on ulcer index, gastric wall mucus content, lipid peroxidation level in stomach tissue and tissue anti-oxidant parameters like superoxide dismutase, reduced glutathione and catalase activity. Pre-treatment of Pep-Up Tablet and Syrup showed significant protection against loss of gastric wall mucus content and ulceration. They also significantly prevented depletion of tissue anti-oxidant parameters in comparison of disease control group. From the present study, it can be concluded that Pep-Up Tablet and Syrup are having significant anti-oxidant property which enhanced the stability of gastric mucosa against the damage caused by water immersion plus restraint induced stress. The gastro-protective effect of Pep-Up Tablet and Syrup on stress induced gastric ulceration supports their clinical application to prevent acid-peptic disorders.