Author(s): Gummalla Pitchaiah, Shaik Samiya, KNSV Lakshmi, Sailaja P

Abstract: Traditionally, a large number of plants are used for the treatment of inflammation and wounds. Murraya koenigii is popular Indian herb and different parts are used in traditional medicine for the treatment of various diseases. However, many studies have not conducted on its fruit potential. Hence, the present study was carried out to investigate anti-inflammatory and wound healing activities of Murraya koenigii fruits in rodents. The anti-inflammatory activity of the Murraya koenigii was based on its effects on carrageenan-induced paw ooedema in rats. Its wound healing effect was investigated using an excision wound model. Four hours after administration, the reduction in carrageenan-induced rat paw ooedema by low dose (100 mg/kg) and high dose (200 mg/kg) of Murraya koenigii was 42.6 and 50.3%, respectively, while ooedema reduction by indomethacin (10 mg/kg) was 55.5%. Topical application of Murraya koenigii fruit extract ointment showed significant (p<0.05) wound closure and epithelialization compared to control. This study demonstrates that the hydroalcoholic extract of Murraya koenigii fruits has significant anti-inflammatory and wound healing properties.