Vol. 5, Issue 3, Part A (2017)
Aqueous extracts from evening primrose seeds (Oenethera biennis) contract isolated uterine tissues but have no effect on isolated cervical tissues
Author(s): Teresa DeGolier, Chelsea Lyle and Andrea Ortmann
Abstract: The effect of aqueous extracts from evening primrose seeds, Oenothera biennis, on mouse uterine tissues and rat cervical tissues in vitro were investigated at various concentrations (10-40 mg) using standard 15 mL organs baths. All extract concentrations used increased the force of uterine contractions; the highest concentrations yielded significant increases (P=0.01972). These contractile forces were slightly greater than those evoked from acetylcholine (10-5 M). Cervical tissues that were pre-contracted with a high potassium solution did not demonstrate any relaxation following 15 min incubations with the evening primrose seed extracts. The badrenergic receptor agonist isoproteronol did relax the cervical tissues by 97% (P=0.05). These results may indicate that some of the evening primrose constituents responsible for (1) uterine contractions are water-soluble and are present in the aqueous extract; and (2) cervical relaxation are primarily lipid-soluble and are present to a greater degree in the oil fraction.
How to cite this article:
Teresa DeGolier, Chelsea Lyle and Andrea Ortmann. Aqueous extracts from evening primrose seeds (Oenethera biennis) contract isolated uterine tissues but have no effect on isolated cervical tissues. International Journal of Herbal Medicine. 2017; 5(3): 10-16.