Author(s): Augustine Bassey, Paul Nwafor and Jude Okokon

Abstract: Enantia chlorantha is a medicinal plant that is used all over Nigeria. The Ibibios of South–South Nigeria use the stem bark of this plant for the treatment of febrile illnesses, stomach upset, toothache and convulsions. This study evaluated the anti-convulsant activities of the extract in rodents. Other pharmacological investigations such as anti-inflammatory, analgesic, anti-pyretic, anti-ulcer and studies were also carried out. Anti-convulsant effect of the extract was assessed using a modified method of Vellucci and Webster (1984) on overnight fasteddult albino mice (25–30g) of both sexes. The extract significantly (p<0.01 – 0.001) delayed the onset of clonic and tonic convulsions in mice induced by PTZ and exerted significant (p<0.01) delay in the onset of clonic and tonic convulsions caused by picrotoxin when compared to control.The above results provide support for the traditional use of Enantia chlorantha stem bark in treating convulsions in South-South Nigeria. Further characterization of the extract is recommended.