Vol. 5, Issue 4, Part A (2017)
Hepatoprotective activity of husk extract and fractions of Zea mays against alloxan-induced oxidative stress in diabetic Rats
Author(s): Jude E Okokon, Mandu Emmanuel Nyong, Grace Emmanuel Essien and Emmanuel Nyong
Abstract: Zea mays L. (Poacae), an annual grass, traditionally used to treat various diseases was evaluated for antioxidative stress and hepatoprotective potentials against alloxan-induced injuries in diabetic rats. Antioxidative stress and hepatoprotective activities of husk extract and fractions (187-748 mg/kg) were assessed by determining oxidative stress markers levels, liver tests and histopathology of liver. The husk extract and fractions caused significant (p<0.05 – 0.001) increases in the levels of oxidative stress markers (SOD, CAT, GPx, GSH) in the liver of the treated diabetic rats. The extract/fractions treatment caused reduction in liver enzymes (ALT and ALP), GGT, total bilirubin, and also increased total protein and albumin levels as well as AST. Histology of liver revealed absence or significant reductions in pathological features in the treated diabetic rats compared to untreated diabetic rats. The GCMS analysis of n-hexane fraction revealed the presence of phytochemical compounds of pharmacological importance. The results show that the husk extract and fractions of Zea mays has antioxidative stress and hepatoprotective potentials which may be due to the antioxidant activities of their phytochemical constituents.
How to cite this article:
Jude E Okokon, Mandu Emmanuel Nyong, Grace Emmanuel Essien and Emmanuel Nyong. Hepatoprotective activity of husk extract and fractions of Zea mays against alloxan-induced oxidative stress in diabetic Rats. International Journal of Herbal Medicine. 2017; 5(4): 43-50.