International Journal of Herbal Medicine
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E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20 NAAS Rating: 3.20
International Journal of Herbal Medicine
Vol. 6, Issue 4, Part A (2018)

Nephroprotective and antioxidant activity of ethanol extract of whole plant Biophytum sensitivum (Linn.) dc on gentamicin-induced renal damage in rats

Author(s): Abhirama BR, Shanmugasundaram R, Raju A and Neethu IS
Abstract: Present study was undertaken to investigate nephroprotective and antioxidant activity of whole plant ethanol extract of Biophytum sensitivum Linn. DC on gentamicin induced-nephrotoxicity in Wistar albino rats. Animals were divided into five groups, containing six animals in each. Gentamicin 100mg/kg/day; i.p., was given to all groups except normal control to induce nephrotoxicity for a period of 8 days in rats. Animals in Group I served as control and Group II as GM-treated or nephrotoxic control. Group III received standard quercetin; group IV received low dose of extract (250mg/kg) and group V received high dose of extract (50mg/kg).Serum levels of blood urea nitrogen, uric acid, creatinine, total protein, albumin, sodium, potassium, calcium, magnesium and antioxidant enzyme activities were determined. This study substantiated and confirmed the ethno-medical usefulness of B. sensitivum as nephroprotective and antioxidant agent.
Pages: 44-47  |  473 Views  17 Downloads
How to cite this article:
Abhirama BR, Shanmugasundaram R, Raju A and Neethu IS. Nephroprotective and antioxidant activity of ethanol extract of whole plant Biophytum sensitivum (Linn.) dc on gentamicin-induced renal damage in rats. International Journal of Herbal Medicine. 2018; 6(4): 44-47.
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International Journal of Herbal Medicine