Vol. 6, Issue 6, Part A (2018)
Preclinical study on cardioprotective effect of ethanolic extract of Eucalyptus globulus against doxorubicin induced cardiotoxicity
Author(s): Pritam Saha Podder, Pijus Madhu, Rajib Das, Md. Abdul Awoal, Nusrat Jahan and Md. Shah Jinat Ullah
Abstract: Doxorubicin is an effective broad-spectrum anthracycline chemotherapeutic agent successfully used in the treatment of a wide range of malignancies. However, the effectiveness of this drug has become limited by the occurrence of dose related cardiotoxicity and heart failure. The aim of the present study was to investigate the potential cardioprotective effect of “Eucalyptus globulus” against doxorubicin induced cardiotoxicity in the Wister albino rats. Animals received either Doxorubicin (3 mg/kg, i.p.) every other day or combination of E. globulus (100mg/kg and 200mg/kg;p.o.) with Doxorubicin or E. globulus (200mg/kg;p.o.) extract alone for 2 weeks. Cardiotoxicity was assessed by recording changes in ECG (increased QT interval), measuring the levels of cardiac marker enzymes such as lactic acid dehydrogenase (LDH), creatinin kinase (CK-MB) at the end of treatment schedule. Treatment with E. globulus (100mg/kg and 200mg/kg) significantly (p<0.05) decreased the levels of cardiac marker enzymes, reversed the changes in ECG and prevented the decrease in heart weight in DOX-treated group. These results suggest that E. globulus has the potential in preventing the cardiotoxic effects induced by Doxorubicin.
How to cite this article:
Pritam Saha Podder, Pijus Madhu, Rajib Das, Md. Abdul Awoal, Nusrat Jahan and Md. Shah Jinat Ullah. Preclinical study on cardioprotective effect of ethanolic extract of Eucalyptus globulus against doxorubicin induced cardiotoxicity. International Journal of Herbal Medicine. 2018; 6(6): 35-39.