International Journal of Herbal Medicine
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E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20 NAAS Rating: 3.20
International Journal of Herbal Medicine
Vol. 7, Issue 6, Part A (2019)

Isolation and characterization of mosquito larvicidal compounds from leaves of Kotschya uguenensis (Taub) F. Whote

Author(s): Baraka Samwel, Ester Innocent, Francis Machumi, William N Kisinza and Matthias Heydenreich
Abstract: At 72h of exposure, the crude extract showed larvicidal activity with LC50 values of 94.01 µg/mL against An. gambiae. Based on bioactivity-guided fractionation, a new ent-halimane type diterpene, named ent-halim-1(10)-ene-15-oic acid (1) together with a known 3-O-methyl-D-chiro-inositol (3) were isolated and identified as the active constituents. Ent-halim-1(10)-ene-15-oic acid (1) and 3-O-methyl-D-chiro-inositol (3) exhibited strong larvicidal activity with LC50 value of 30.05 and 80.73 µg/mL µg/mL, respectively (>95% CI) after 72 h post exposure. The extract and the two compounds (1 and 3) had no significant activity at 24 and 48 h. However the ent-halim-1(10)-ene-15-oic acid (1) demonstrated strong activity against An. gambiae with significant different being observed against the extract and compound 3. The results indicated that 80% aqueous ethanol leaves extract of K. uguenensis and the two isolated constituents have potential for development in the control of An. gambiae larvae.
Pages: 01-04  |  339 Views  103 Downloads
How to cite this article:
Baraka Samwel, Ester Innocent, Francis Machumi, William N Kisinza and Matthias Heydenreich. Isolation and characterization of mosquito larvicidal compounds from leaves of Kotschya uguenensis (Taub) F. Whote. International Journal of Herbal Medicine. 2019; 7(6): 01-04.
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