Vol. 8, Issue 3, Part A (2020)
Antiproliferative efficacy of sorghum bran extracts against MCF-7 breast cancer cell lines
Author(s): Sivakumar Eniya, Thangavel Thirunavukkarsu and S Mohandass
Abstract: Over the past decade, there has been an increasing interest in using nanotechnology for cancer therapy. The development of smart targeted nanoparticles (NPs) that can deliver drugs at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating primary and advanced metastatic tumors. The present study was aimed to investigate the in vitro cytotoxicity effect of biogenic Zinc nanoparticles ZnONPs) against human breast cancer (MCF-7) cells towards the development of anticancer agent. Nanobiocomposite of zinc oxide nanoparticles conjugated with Sorghum Bran was produced and was confirmed using maximum UV–Vis absorption at 340 nm in the present work. The anti-cancerous nature of the synthesized zinc oxide conjugated nanobiocomposite on MCF-7 cell line was studied using MTT assay. The viability of the MCF-7 cells was decreased to 48% when it was treated with Sorghum bran conjugated zinc oxide nanobiocomposite. There was an immediate induction of cellular damage in terms of loss of cell membrane integrity, oxidative stress and apoptosis were found in the cell which treated with ZnONPs. This may be a first report on anti-MCF-7 property of biogenic ZnONPs, but mechanism needs to be elucidated.
How to cite this article:
Sivakumar Eniya, Thangavel Thirunavukkarsu and S Mohandass. Antiproliferative efficacy of sorghum bran extracts against MCF-7 breast cancer cell lines. International Journal of Herbal Medicine. 2020; 8(3): 36-38.