"International Journal of Herbal Medicine"

Volume 1, Issue 2

 

Quassinoids and Their Chemotaxonomic Significance

 

Author(s): Bipin Chandra Joshi *, Ram Prakash Sharma, Anakshi Khare
Department of Chemistry, L.S.M. Govt. P. G. College, Pithoragarh-262502.

Abstract: The quassinoids are a group of complex, highly oxygenated, degraded triterpene mostly found in Simaroubaceae family. Two quassinoids (degraded triterpenes), 1 and 2 were isolated first time from the stem bark of Ailanthus excelsa. Compound 1 is C₁₉ quassinoid. C₁₉ quassinoid derived biogenetically from a C₂₀ quassinoid, via a 1,2 –dioxo derivative. The structural elucidation is based on the analysis of spectroscopic data. Interest in these quassinoids has increased enormously in recent years due in part to the finding of the American National Cancer Institute that these compounds display marked antileukamic activity. The ways in which plants interact with other organisms in an environment are complex. Ailanthus also produces toxins in its root, bark and leaves. These toxins inhibit the growth of other plants. The isolated quassinoids are currently being studied as a possible source of a natural herbicide. Extracts of this plant have anti-insect activity and anti-tuberculosis activity.

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