"International Journal of Herbal Medicine"

Volume 1, Issue 3

 

Anti-inflammatory Activity of Characterized Compound Diosgenin Isolated from Tinospora malabarica Miers in Ann. (Menispermaceae) in Animal Model

 

Author(s): D. Punitha1, M. R.Udhayasankar2, U. Danya3, K. Arumugasamy4, A. Shalimol5
1. Department of Botany, Providance College for Women (Autonomous), Coonoor-04, The Nilgiris. Tamil Nadu
2. PG and Research Department of Botany, Kongunadu Arts and Science College (Autonomous), Coimbatore 641029, Tamil Nadu.
3. PG and Research Department of Botany,Sri Parasakthi College for Women (Autonomous), Courtallam-627802, Tamil Nadu
4. PG and Research Department of Botany, Kongunadu Arts and Science College (Autonomous), Coimbatore 641029, Tamil Nadu
5. PG and Research Department of Botany,Kongunadu Arts and Science College (Autonomous), Coimbatore 641029, Tamil Nadu.

Abstract: At concentrations of diosgenin isolated from Tinospora malabarica was investigated in chemically-induced inflammation rodents’ model. It showed a significantly (P < 0.01) reduced mean paw edema volume at 3h after carrageenan injection. These extracts have exhibited anti-inflammatory activity in a dose-dependent manner with the per cent inhibition of paw edema, as compared with the control group. This result indicated that the characterized compound, diosgenin at the dose of 400µg/kg.b.wt showed a maximum anti-inflammatory activity of 82.25% as compared to the reference drug, indomethacin (82.01%). Therefore, our studies support the use of active constituents from T. malabarica in treating inflammations.

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