"International Journal of Herbal Medicine"

Volume 2, Issue 2


Biochemical evaluation of anti diabetic activity of aqueous extract of Gmelina arborea in Alloxan induced albino rats


Author(s): Kumaresan P, Jeyanthi KA, Kalaivani R

Abstract: Diabetes mellitus is a clinical syndrome, a group of metabolic diseases which cells do not respond to the insulin that is produced. All forms of diabetes have been treatable since insulin became available in 1921. Though drugs are plenty for the treatment of diabetes, none is found to be ideal due to undesirable side effects and diminution after prolonged use. In the traditional system of Indian medicine, formulation with extracts of plant parts is used as the drug of choice as antidiabetic and lipid-lowering agents. Although phytotherapy continues to be used in several countries, few plants have received scientific or medical scrutiny. Based on folkloric use, the present study was designed to evaluate the antidiabetic potential of Gmelina arborea is a fast growing deciduous tree. Male albino rats of the Wister strain weighing around 90-160 g were used for this study. The rats were 10-12 weeks of age can be used in this study. 100 mg of leaf powder were dissolved in 1000 ml of water. This solvent was used to treat the alloxan induced rats for 21 days. The present study reveals the changes in the level of HbA1c, Glucose, Urea, Creatinine, Protein, Albumin, Globulin, SGOT, SGPT and ALP. The results of the present study indicate that the plant extract is nontoxic and possess antidiabetic activity.


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