Author(s): Moumita Dutta, Utpal Kumar Biswas, Runu Chakraborty, Piyasa Banerjee, Arun Kumar, Utpal Raychaudhuri

Abstract: The complications of diabetes are mainly as a result imbalance between oxidative stress and antioxidant defence. Several plant products are being reported to be effective in this condition including Swietenia macrophyllaking. The aim of this study was to find out whether the aqueous extract of these seeds have any effect on the antioxidant enzyme activity in liver and kidney tissues and on the total oxidative stress in plasma in the experimental type II diabetic rats. Streptozotocin was used to induce diabetes except in the control group. The activities of the antioxidant enzymes in the tissues extracts. The activities of the antioxidant enzymes in the tissues extracts and total oxidative stress in plasma were estimated using standardized methods.The extract fed rats show significantly increased activity of superoxide dismutase (U/mg), Catalase (U/mg) and glutathione peroxidise (U/mg) in the liver (5.12±0.21, 45.03±1.19, 2.69±0.02 respectively) and kidney tissues (5.66±0.06, 89.61±0.27, 2.93±0.01, respectively) than the diabetic control animals (3.08±0.21, 33.01± 1.36, 1.94±0.08 in liver and 3.60±0.07, 40.42±1.73, 2.21±0.05 in kidney respectively). Total oxidative stress was found significantly decreased (82.5±0.05 FORT U) in the animals treated with extract compared to the diabetic controls (100±0.63 FORT U).  We conclude that the extract ofSwietenia macrophylla king seeds effectively reduce the oxidative stress in plasma as well as increase the antioxidant enzyme defence in the antioxidant enzyme defence in the tissues of experimental diabetic rats.