International Journal of Herbal Medicine
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20 NAAS Rating: 3.20
International Journal of Herbal Medicine
Vol. 2, Issue 2, Part A (2014)

Evaluation of gastro-protective effect of Pep-Up Tablet and Pep-Up Syrup on water immersion plus restraint stress-induced gastric ulcer in rats

Author(s): Hardik Soni, Sweta Patel, Arindam Paul, Ghanshyam Patel
Abstract: Stress is an adaptive physiological response to disruption of homeostasis. Stress-induced gastric ulceration is a typical example of stress-associated organ injuries. The present study was carried out to evaluate gastroprotective effect of Pep-Up Tablet and Syrup, proprietary Ayurvedic formulations, on water immersion plus restraint stress-induced gastric ulcer in rats. Both test drugs were studied for their effect on ulcer index, gastric wall mucus content, lipid peroxidation level in stomach tissue and tissue anti-oxidant parameters like superoxide dismutase, reduced glutathione and catalase activity. Pre-treatment of Pep-Up Tablet and Syrup showed significant protection against loss of gastric wall mucus content and ulceration. They also significantly prevented depletion of tissue anti-oxidant parameters in comparison of disease control group. From the present study, it can be concluded that Pep-Up Tablet and Syrup are having significant anti-oxidant property which enhanced the stability of gastric mucosa against the damage caused by water immersion plus restraint induced stress. The gastro-protective effect of Pep-Up Tablet and Syrup on stress induced gastric ulceration supports their clinical application to prevent acid-peptic disorders.
Pages: 27-30  |  1006 Views  6 Downloads
How to cite this article:
Hardik Soni, Sweta Patel, Arindam Paul, Ghanshyam Patel. Evaluation of gastro-protective effect of Pep-Up Tablet and Pep-Up Syrup on water immersion plus restraint stress-induced gastric ulcer in rats. Int J Herb Med 2014;2(2):27-30.
Call for book chapter
Journals List Click Here Research Journals Research Journals
International Journal of Herbal Medicine