Author(s): Rajashree Rane, Divya Gangolli, Madhavi Vartak, Kavita Salkar, Ashish Suthar, Sachin Kundalwal

Abstract: Calcium sennosides A and B extracted from Cassia angustifolia has been used as stimulant laxative in herbal medicine. It has got medicinal value, hence is to be monitored and administered in appropriate dosage form. In this study attempts were made to analyse tablet formulations containing sennosides as the only active ingredient, as well as sennosides in combination with other purgatives. The study focuses on dissolution profile, disintegration time along with analytical evaluation as per the established monograph requirement like description, disintegration time, average weight, LOD, residue on ignition, pH, microbial evaluation, HPTLC fingerprinting, Assay - Content of sennosides A and B by Fluorometry. Also additionally tested for content of tannins, calcium, and iron. Dissolution profile was made for all samples. In-house single ingredient senna tablet preparation with lowest DT and appreciable dissolution can be considered as ideal laxative. Presence of calcium sennosides can give very good laxative effect.