Author(s): Varsha Jadhav, Vaibhav Kalase and Poonam Patil

Abstract: Holigarna grahamii belongs to family Anacardiaceae and commonly known as ‘Ranbibba’. It produces white latex which is allergenic and causes contact dermatitis. The present investigation was design to determine the bioactive constituents from various plant parts such as Latex, Stem Bark, Leaves, Mature fruits and Ripened fruits of H. grahamii using GC-MS. The GC-MS analysis of the methanolic extract revealed the presence of forty four bioactive compounds with valuable biological activities, including the allergic Melamine. The major chemical constituents are Quinic acid (5.72%), 1,2,3-Benzenetriol (42.25%), Melamine (3.07%), Pentanoic acid, 4-oxo- (1.40%), Myristic acid (3.36%), Oleic Acid (0.49%).