Author(s): Atul Kumar Gangwar, Ashoke K. Ghosh, Vikas Saxena

Abstract: The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats. The anti-inflammatory action was studied by Plethysmometer method. The ethanolic extract of Vitex negundo roots was screened for phytochemical analysis and revealed the presence of all components. The adult rats were divided into four groups of six each and maintained under ideal laboratory conditions. Group I was taken as control and group II treated with the standard drug Indomethacin (10 mg/kg), the ethanolic extract of Vitex negundo root 200 mg/kg and 400 mg/kg were fed to group III and IV. It is observed that the ethanolic extract of Vitex negundo roots shows considerable anti-inflammatory effect by using carrageenan induced rat paw edema method. The higher dose groups of Vitex negundo rootextract (400 mg/kg) were revealed more activity than their corresponding lower dose.