Vol. 3, Issue 5, Part A (2015)
In vivo Investigation of antiamnesic effect of Asparagus racemosus root extract in scopolamine induced amnesic mice
Author(s): Prasad Jagdish, Chittora Reena, Suhalka Pooja, Bhatnagar Maheep
Abstract: Asparagus racemosus, mentioned as Medhya Rasayanas in ancient Ayurveda which improve brain function, memory, and intelligence. The present study was focused to investigate its effects on learning and memory. Study was carried out on young adult male mice (25 gm ± 5 wt.). Elevated plus maze and Passive avoidance paradigm were used for the study. Methanolic root extract (100 mg/ kg wt. p. o.) was given orally. Experimental animals were given Scopolamine hydrobromide (1 mg/ kg wt. i. p.) was administered for 7 successive days to adult mice before starting the AR treatment. Intra peritoneal injection of scopolamine increased the TL in exteroceptive behavioral model Elevated plus maze andremarkable decrease in step through transfer latencyin Passive avoidance paradigm. Pretreatment for 7 successive days of asparagus racemosus reversed these effects of scopolamine in mice. ThusAsparagus racemosus root extract possesses memory enhancing potential and validating its utility as a curing drug for treatment of dementia.
How to cite this article:
Prasad Jagdish, Chittora Reena, Suhalka Pooja, Bhatnagar Maheep. In vivo Investigation of antiamnesic effect of Asparagus racemosus root extract in scopolamine induced amnesic mice. Int J Herb Med 2015;3(5):20-24.