Objective: to determine the efficacy and the possible side effects of coconut oil in the treatment of molluscum contagiosum.

Patients and Methods: 40 pediatric patients divided into two groups, 20 patients use coconut oil and other 20 patients use olive oil. All patients use the topical therapy twice daily for two weeks and followed for another two months.

Result: complete clearance was noticed in (40%), while in the control group only (5%) has complete clearance,. Only (25%) in the first group reveal no response at all while in the control group (90%) showed no reduction in the number of lesions.

Conclusion: coconut oil has an acceptable effective and preventive role in management of molluscum contagiosum infection