Author(s): Khushboo Jethva, Dhara Bhatt and Maitreyi Zaveri

Abstract: Tuberculosis is one of the leading infectious disease and health burden in the world. It has been estimated that, one third of world’s population including 40% from India estimated to be infected with tuberculosis. As plants are the important sources of diverse range of bioactive principles. The revival of interests in plant derived drugs is mainly due to the current widespread belief that green medicine is safe and more dependable than expensive synthetic drugs, which have adverse side. In this study nine healthy plants with medicinally potential were collected and different extracts were prepare to evaluate its phytochemical study and anti-tubercular activity on Mycobacterium smegmatis using two different models. There are many similarities between Mycobacterium smegmatis and the much more virulent obligate pathogens that are Mycobacteria. On the basis of both the models, form nine selected plants three plants A. vasika, O. sanctum and A. galanga shows maximum anti-tuberculosis activity at the MIC 100 μg/ml, 250 μg/ml and 250 μg/ml respectively. The present study has revealed the importance of plant extracts to control Mycobacterial infections which are being a threat to human health and for the development of alternate, safe and effective medicines.