Author(s): Monu Yadav and Milind Parle

Abstract: Natural compounds are able to protect the central nervous system neuropsychiatric disorders including psychosis. Psychosis is a complex and chronic disorder, characterised by group of symptoms such as stereotypic behaviours, hyperlocomotor activity etc. Typical and atypical antipsychotic drugs are available to treat these behavioural changes. However, these synthetic agents exert some serious side effect. Therefore, we have chosen eucalyptus oil and studied its protective effect in Ketamine induced stereotypic behaviours. Ketamine; 50mg/kg, i.p. was used to produce stereotypic behaviours such as turning, falling, weaving and head bobbing in mice. Eucalyptus oil (EO) at the dose of 500, 1000 and 2000 mg/kg, p.o, were administered for 10 consecutive days. Olanzapine; 5mg/kg, i.p. and haloperidol; 1mg/kg, i.p. were used as reference drugs in this study. Eucalyptus oil (EO) was significant to decrease the Ketamine produced stereotypic behaviours dose dependently. These results revealed that Eucalyptus oil (EO) possesses beneficial effective in Ketamine induced stereotypic behaviours.