International Journal of Herbal Medicine
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E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20 NAAS Rating: 3.20
International Journal of Herbal Medicine
Vol. 5, Issue 2, Part B (2017)

Evaluation of wound healing and antimicrobial physiognomies of alcoholic extract of Ocimum sanctum (basil) in diabetic rabbit model

Author(s): Nimmy K Francis, Harpreet S Pawar, Nabam Peter, Gaurav Biswas, Jayjeet Majumdar, Anirban Mitra and Analava Mitra
Abstract: Diabetes is a chronic metabolic syndrome characterized by impaired wound healing and secondary wound infections attributing to the economy. The plant Ocimum sanctum (basil) is widely used owing to its chemo-immuno modulatory, antimicrobial and anti-inflammatory characteristics. Study aims to elucidate therapeutic potential of alcoholic extract of basil in wound healing in diabetic rabbit model. Animals were divided into wounded control treated with povidone Iodine and test with basil extract. Semi-quantitative and qualitative evaluation of tissue architecture and immuno-histochemistry encompassing collagen I and III studies expressed swift regeneration of injured epidermis in basil extract treated wound in comparison to control. This is articulated by organized dermal collagen deposition with collagen I to III ratio resembling normal skin, wound area measurement and absence of clinical signs of wound infection. Encouraging primary evidences for swifter wound healing requisites further experimental validation for the translation and standardization of the product from bench to bedside.
Pages: 91-97  |  1155 Views  27 Downloads
How to cite this article:
Nimmy K Francis, Harpreet S Pawar, Nabam Peter, Gaurav Biswas, Jayjeet Majumdar, Anirban Mitra, Analava Mitra. Evaluation of wound healing and antimicrobial physiognomies of alcoholic extract of Ocimum sanctum (basil) in diabetic rabbit model. Int J Herb Med 2017;5(2):91-97.
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International Journal of Herbal Medicine