International Journal of Herbal Medicine
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E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20 NAAS Rating: 3.20
International Journal of Herbal Medicine
Vol. 5, Issue 3, Part A (2017)

Aqueous extracts from evening primrose seeds (Oenethera biennis) contract isolated uterine tissues but have no effect on isolated cervical tissues

Author(s): Teresa DeGolier, Chelsea Lyle and Andrea Ortmann
Abstract: The effect of aqueous extracts from evening primrose seeds, Oenothera biennis, on mouse uterine tissues and rat cervical tissues in vitro were investigated at various concentrations (10-40 mg) using standard 15 mL organs baths. All extract concentrations used increased the force of uterine contractions; the highest concentrations yielded significant increases (P=0.01972). These contractile forces were slightly greater than those evoked from acetylcholine (10-5 M). Cervical tissues that were pre-contracted with a high potassium solution did not demonstrate any relaxation following 15 min incubations with the evening primrose seed extracts. The badrenergic receptor agonist isoproteronol did relax the cervical tissues by 97% (P=0.05). These results may indicate that some of the evening primrose constituents responsible for (1) uterine contractions are water-soluble and are present in the aqueous extract; and (2) cervical relaxation are primarily lipid-soluble and are present to a greater degree in the oil fraction.
Pages: 10-16  |  1294 Views  35 Downloads
How to cite this article:
Teresa DeGolier, Chelsea Lyle, Andrea Ortmann. Aqueous extracts from evening primrose seeds (Oenethera biennis) contract isolated uterine tissues but have no effect on isolated cervical tissues. Int J Herb Med 2017;5(3):10-16.
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International Journal of Herbal Medicine