Author(s): Augustine Ini Lawrence Bassey, Paul Alozie Nwafor and John Akpan Udobang

Abstract: Male adult albino rats (150 – 180g) were used for the experiment. They were randomized into six (6) groups of six (6) animals each. Food was withdrawn 24 hr and water 2 hr before the commencement of the experiment. Three models were used for this experiment (indomethacin induced ulcer, ethanol and reserpine induced ulcer). Groups 2-4 were pretreated with the extract at doses of 32.40mg/kg, 64.80 mg/kg and 96.20 mg/kg. Cimetidine was used as the standard drug. There was a progressive decline in ulcer index of the rats pre-treated with the extract. The decline was dose-dependent and statistically significant (p<0.05–0.001) relative to control. The extract also showed a progressive preventive ratio. This effect was dose-dependent. The above results provide support for the traditional use of Enantia chlorantha stem bark in treating gastric conditions in Akwa Ibom state Nigeria.