International Journal of Herbal Medicine
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20 NAAS Rating: 3.20
International Journal of Herbal Medicine
Vol. 5, Issue 4, Part B (2017)

Herbal preparations prevent beta-amyloid peptide induced hippocampal cell damage

Author(s): Hayk Harutyunyan, Svetlana Sharoyan, Alvard Antonyan and Sona Mardanyan
Abstract: The aggregates of Aβ(1-40) and Aβ(1-42) peptides are considered as the pathological hallmarks of Alzheimer's disease. The present work examined the ability of several plant preparations to protect the viability of hippocampal cells in the presence of aggregated Aβ peptides. The inhibition of the viability of rat hippocampal cells by the preliminarily aggregated peptides down to 20±2.5% of control was proved. In the presence of aggregated Aβ peptides, the cell viability was saved at 51-114% of control in the medium containing the ethanol extracts from grape and sorrel leaves, rose petals, melilot, phenol glycoside and flavonoid fractions from these extracts. The DNA-comet analysis evidenced the cell integrity conserving by the extracts, but not by the phenol glycoside fraction from rose petals, which significantly protected the cell viability from aggregated Aβ(1-40) and Aβ(1-42) (IC50 = 0.2 ± 0.02 and 2.1 ± 0.7 µg/ml, respectively). Conclusion: the studied plants can be considered as sources for neuroprotecting agents.
Pages: 99-105  |  876 Views  19 Downloads
How to cite this article:
Hayk Harutyunyan, Svetlana Sharoyan, Alvard Antonyan, Sona Mardanyan. Herbal preparations prevent beta-amyloid peptide induced hippocampal cell damage. Int J Herb Med 2017;5(4):99-105.
Call for book chapter
Journals List Click Here Research Journals Research Journals
International Journal of Herbal Medicine