Vol. 5, Issue 5, Part A (2017)
Antiulcer activities of the ethanol root extract of Setaria megaphylla (Steud) T. Dur and schinz in rat
Author(s): John A Udobang, Augustine IL Bassey and Jude E Okokon
Abstract: Setaria megaphylla
(Steud) T. Dur and Schinz (Poaceae), is a medicinal plant used in South-South Nigeria to treat malaria, hemorrhoids, urethritis, inflammation, diabetes, fevers and various pains . While some researches have been carried out to authenticate the uses of the leaves of the plant, very little research has been done on the root extract and its fractions.
This work is therefore designed to investigate the antiulcer potential of Setaria megaphylla ethanol root extract. The ethanol root extract (150, 300, 450 mg/kg) was investigated for indomethacin, ethanol and histamine- induced ulcers in rats using standard procedures. The extract caused a progressive, dose-dependent and statistically significant (p<0.05 - 0.001) decline in ulcer index of the rats pretreated with the extract and a dose-dependent progressive preventive ratio. The observed effect of the extract (150 - 450 mg/kg) was weak compared to the standard drugs, cimetidine 100 mg/kg and propranolol 40mg/kg respectively used in the indomethacin and ethanol models, but the 450 mg/kg dose of the histamine model had a higher effect than the standard drug, cimetidine 100 mg/kg. The results of this study revealed that the ethanol root extract of S. megaphylla possesses anti-ulcer effects from its phytochemical components.
How to cite this article:
John A Udobang, Augustine IL Bassey, Jude E Okokon. Antiulcer activities of the ethanol root extract of Setaria megaphylla (Steud) T. Dur and schinz in rat. Int J Herb Med 2017;5(5):22-26.