Vol. 5, Issue 5, Part A (2017)
Evaluation of nephroprotective effects of Setariamega phyla (Steud) T. Durand sphinz (Poaceae) root extract on paracetamol-induced in juryin rats
Author(s): John A Udobang and Jude E Okokon
Abstract: Setariamega phylla
(Steud) T. Dur and Schinz (Poaceae), is apopular medicinal plant used by the indigenes of Nigeria’s Niger Delta region to treat malaria, hemorrhoids, urethritis, inflammation, diabetes, fevers and various pains . Due to the claims by the traditional users of this plants’ about its effectiveness, it becomes essential to investigate the potential toxic or protective effect of Setariamega phylla
. This work is therefore designed to investigate the nephroprotective effects of Setariamega phyla
ethanol root extract.
Setariamega phylla ethanol root extract (150, 300, 450 mg/kg) was investigated for its biochemical and histological effects in rats kidneys using standard procedures. There was decrease in weights of kidneys. Reductions in urea and creatinine levels of animals pretreated with the extract (150 - 450 mg/kg) when compared to the paracetamol group was also seen. Histology showed hepatotoxic and nephrotoxic effects in the paracetamol group which were absent in the extract treated groups. The results of this study revealed that S. megaphylla ethanol root extract possesses nephroprotective effect.
How to cite this article:
John A Udobang, Jude E Okokon. Evaluation of nephroprotective effects of Setariamega phyla (Steud) T. Durand sphinz (Poaceae) root extract on paracetamol-induced in juryin rats. Int J Herb Med 2017;5(5):27-31.