Author(s): T.Mangilal, KSK Rao Patnaik, R Shyam Sunder and S Anuradha Bai

Abstract: Herbal formulations have growing demand in the world market and the plants have been reported in the literature having good anti- microbial, anti-oxidant and anti-inflammatory activity. In this study cream was formulated based on the anti-oxidant potential of herbal extracts and its evaluation. Green tea leaves were a shade dried and extracted using a Soxhlet extraction method. The cream was formulated with Neem oil, Jamul seed powder, olive oil of different concentrations namely F₁, F₂, F₃ and F₄. The cream was stable during stability studies according to ICH guidelines 30±2 ⁰C / 50±5% RH and 40±2 ⁰C / 75±5% RH for two months. The evaluations of all formulations were done on different parameters like pH, spreadability, stability etc. Formulations F₃ and F₄ showed good spreadability, good consistency, homogeneity with good appearance, pH, and no evidence of phase separation and ease of removal. The formulation F3 and F4 shows no redness, edema, inflammation and irritation to the skin during irritancy studies. These studies suggest that the composition of extracts and base of cream of F4 is more stable and safe, it may produce synergistic action. It can be concluded that herbal cream without side effects having anti-oxidant property can be used as provision of a barrier to protect the skin and avoid aging of the skin.