Vol. 7, Issue 5, Part A (2019)
The recovery of bone and cartilage in an experimental model of osteoporosis under the action of a new cost-effective phytotherapeutic composition (Fitokost New)
Author(s): Volkov Evgeniy Egorovich, Alexey Mikhailovich Vasilenko, Vladimir Fedorovich Korsun, Marina Sergeevna Izvolskaia and Elena Vladimirovna Korsun
Abstract: The problem relevance is determined by the prevalence of osteoporosis, lack of efficacy and the iatrogenic effects of drug therapy. Despite traditional medicine practices many various methods of herbal-therapy, the scientific data on its use in osteoporosis are scarce; they are presented mainly by researchers outside Russia. It was previously shown that the multicomponent Russian herbal preparation “Fitokost” corrects cartilaginous and bone tissue disorders that are caused by prednisolone in an experimental model of osteoporosis. The study objective is to determine the efficacy of a new, more economical phytocomposition “Fitokost New” in the treatment of osteoporosis in an experiment. The experiments were performed on Balb/c 3-month-old mice in an osteoporosis model. The experiment started on 15.01.2018 and completed by 28.02.2018. The animals were divided into 6 groups. Group 1, the control group, was comprised of intact animals. The animals in groups 2–6 were intramuscularly injected with prednisolone (1.0 mg/mouse) on daily basis, for 14 days. The animals in group 2 were sacrificed at the end of the last injection of prednisolone. The animals in group 3 did not receive the phyto-preparation for 30 days. The animals in group 4 received the herbal preparation “Fitokost” (50 mg / mouse) at the end of the last injection of prednisolone (that is day 15) – orally, daily, for 30 days. The animals in groups 5 and 6 received the new phyto-composition “Fitokost New” at the end of the last injection of prednisolone, at doses of 50 and 5 mg/mouse respectively, for 30 days. The experiment revealed a dose-dependent reparative effect of “Fitokost New”, characterized by reduced number of chondroblasts and bone tissue regeneration, like in the case of “Fitokost” preparation. The efficacy of “Fitokost New”, which has a significantly smaller number of components compared with the previously obtained “Fitokost” preparation, is not inferior to it in terms of the ability to restore cartilaginous and bone tissue in the osteoporosis model.
How to cite this article:
Volkov Evgeniy Egorovich, Alexey Mikhailovich Vasilenko, Vladimir Fedorovich Korsun, Marina Sergeevna Izvolskaia, Elena Vladimirovna Korsun. The recovery of bone and cartilage in an experimental model of osteoporosis under the action of a new cost-effective phytotherapeutic composition (Fitokost New). Int J Herb Med 2019;7(5):52-55.