International Journal of Herbal Medicine
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E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20 NAAS Rating: 3.20
International Journal of Herbal Medicine
Vol. 8, Issue 4, Part B (2020)

Fraction of latex of Euphorbia umbellata induced inhibitory proliferation in triple negative breast tumor cell

Author(s): Laertty Garcia de Sousa Cabral, Monique Gonçalves Alves, Gabrielle Otilia Dias de Souza, Luiza Stolz Cruz, Flávio Luís Beltrame, Arthur Cássio de Lima Luna and Durvanei Augusto Maria
Abstract: The objective of this study was to evaluate the antitumor potential of the acetate and chloroform fractions extracted from Euphorbia umbellatalat ex. The cytotoxicity of fractions was evaluated by the MTT colorimetric assay after 24 and 48h at concentrations ranging from 2-30 μg/mL, also the mitochondrial electrical potential by confocal microscopy. The cell cycle, the percentage of fragmented DNA, and the mitochondrial electrical potential were quantified by flow cytometry. Our results suggest that the cytotoxicity of fractions occurs due to the modulation of the apoptotic pathway, a fact that corroborates with compounds already identified from chemical alkaloids groups, with the fractions isolated by acetate and chloroform being those that presented better results in this and previous results antitumor potential new drugs developed by our group.
Pages: 93-100  |  103 Views  49 Downloads
How to cite this article:
Laertty Garcia de Sousa Cabral, Monique Gonçalves Alves, Gabrielle Otilia Dias de Souza, Luiza Stolz Cruz, Flávio Luís Beltrame, Arthur Cássio de Lima Luna, Durvanei Augusto Maria. Fraction of latex of Euphorbia umbellata induced inhibitory proliferation in triple negative breast tumor cell. Int J Herb Med 2020;8(4):93-100.
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International Journal of Herbal Medicine