International Journal of Herbal Medicine
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E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20 NAAS Rating: 3.20
International Journal of Herbal Medicine
Vol. 8, Issue 5, Part B (2020)

Evaluation of hepatoprotective activity of ayurvedic Amritarishta

Author(s): Md. Abdur Rouf, Nowshin Laila Mitu, Ananta K Das, Md. Samiul Huq Atanu
Abstract: Amritarishta (AMR), an ayurvedic preparation, is widely used as a traditional medicine in the treatment of pain & fever in the rural population. Hepatoprotective effect of AMR was investigated through Paracetamol Induced Hepatotoxicity Model. It was administered at 2.5, 5 and 10 ml/kg dose of AMR to Sprague-Dawley rats. Obtained data was analyzed by One-way ANOVA followed by Tukey posthoc analysis. In paracetamol induced hepatotoxicity model, AMR exhibited dose dependent and statistically significant hepatoprotective effect upto 5ml/kg dose evident by its suppressive effect on elevation of different serum hepatic enzymes and lipid peroxidation of liver caused by chronic paracetamol overdose. However, the higher dose (10ml/kg) of AMR failed to be proved better hepatoprotective than that of 5ml/kg dose. AMR, at the dose of 5ml/kg, was able to inhibit serum AST, ALT, Bilirubin, ALP and liver lipid peroxidation was comparable to standard Silymarin at 100mg/kg dose, elicited suppressive activity of 70.1% (p<0.01), 80.72% (p<0.001), 78.57% (p<0.01), 89.55% (p<0.001) and 70.32% (p<0.01) respectively. The results suggest that AMR has good potential as hepatoprotective agent.
Pages: 108-115  |  23 Views  7 Downloads
How to cite this article:
Md. Abdur Rouf, Nowshin Laila Mitu, Ananta K Das, Md. Samiul Huq Atanu. Evaluation of hepatoprotective activity of ayurvedic Amritarishta. Int J Herb Med 2020;8(5):108-115.
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