Author(s): Md. Abdur Rouf, Nowshin Laila Mitu, Ananta K Das, Md. Samiul Huq Atanu

Abstract: Amritarishta (AMR), an ayurvedic preparation, is widely used as a traditional medicine in the treatment of pain & fever in the rural population. Hepatoprotective effect of AMR was investigated through Paracetamol Induced Hepatotoxicity Model. It was administered at 2.5, 5 and 10 ml/kg dose of AMR to Sprague-Dawley rats. Obtained data was analyzed by One-way ANOVA followed by Tukey posthoc analysis. In paracetamol induced hepatotoxicity model, AMR exhibited dose dependent and statistically significant hepatoprotective effect upto 5ml/kg dose evident by its suppressive effect on elevation of different serum hepatic enzymes and lipid peroxidation of liver caused by chronic paracetamol overdose. However, the higher dose (10ml/kg) of AMR failed to be proved better hepatoprotective than that of 5ml/kg dose. AMR, at the dose of 5ml/kg, was able to inhibit serum AST, ALT, Bilirubin, ALP and liver lipid peroxidation was comparable to standard Silymarin at 100mg/kg dose, elicited suppressive activity of 70.1% (p<0.01), 80.72% (p<0.001), 78.57% (p<0.01), 89.55% (p<0.001) and 70.32% (p<0.01) respectively. The results suggest that AMR has good potential as hepatoprotective agent.