Author(s): Abas Mahammed, Habtamu Mitiku and Jemal Mohammed

Abstract: Wound infections remain one of the most common bacterial infections due to microbial drug resistance toward commonly used antimicrobials. The aim of this study was to evaluate in vitro antibacterial activity of Jasminum floribundum, Euphorbia hirta, Euphorbia abyssinica, Sarcophyte piriei, Commiphora myrrha extract used in traditional treatment of common human wound infection. The test was done on standard bacterial strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Streptococcus pyogenes, Proteus mirabilis, and Klebsiella pneumoniae using disc diffusion techniques and Minimum inhibitory concentration. The Result of plant extracts exhibited inhibition zones ranging from 10 ± 2 mm to 24.9 ± 0.9 mm diameter. The Minimum inhibitory concentration value of plant ethanolic extracts against the tested bacteria ranged from 7.8 mg/ml extract of Euphorbia hirta on S. pyogenes and Proteus mirabils and Jasminum floribundum on Klebsiella pneumoniae to 250.00 mg/ml. Further in vivo antibacterial activity and toxicity test are recommended for confirming efficacy and safety of these herbal medicines.