Author(s): Kezia Eggiova Ananda, Ika Rahayu and Kris Herawan Timotius

Abstract: The accentuated increase in the use of Gynura procumbens leave as edible leave, and herbal medicine to treat diseases makes it is necessary to evaluate information available on its antioxidant and antimicrobial activities. This review aims to compile a comprehensive report on total phenolics and flavonoids compounds in the various extract of Gynura procumbens leave; understand their antioxidant and antimicrobial activities; and its administration. Articles were searched via PubMed and Google scholar, and screened according to the criteria. The highest TPC is ethyl acetate extract, but the most TFC is ethanol extract. As concentrated extracts, ethyl acetate extracts have the highest antioxidant activity, followed by ethanol extract. Both inhibit the growth of Gram-positive and gram-negative bacteria, yeast, and fungi. As a diluted extract, the aqueous extract has lower antioxidant and antimicrobial activity than ethyl acetate and ethanol extracts. Commercial preparation of Gynura procumbens is available in the market. Herbal medicine delivery for Gynura procumbens leaves can be prepared as herbal drink, concentrated capsule/tablet, and topical medicine. The high TPC and TFC, antioxidant and antimicrobial activities are found mainly in concentrated ethyl acetate and ethanol extract that can be administrated as tablet/capsule and topical preparation. The aqueous extract should be considered as diluted preparation that good as a herbal drink or as capsule containing concentrated extract.