International Journal of Herbal Medicine
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E-ISSN: 2321-2187, P-ISSN: 2394-0514   |   Impact Factor: RJIF 5.20
International Journal of Herbal Medicine
Vol. 9, Issue 3, Part A (2021)

Role of medicinal plants on inflammatory diseases: A review

Author(s): Rashmi KS and Shashikala MD
Abstract: Medicinal plants are widely used to promote good health and treat diseases. However due to lack of standardized formulations and systematic studies such as pharmacological target and mechanism of action, it has not been developed as mainstream pharmacotherapy. Over a decade of studies provide a compelling evidence for targeting Nrf2 for treatment of oxidative stress-driven chronic disease including COPD, asthma, rhinosinusitis, cardiovascular disease, diabetes, Parkinson’s disease and Alzheimer disease. Transcription factor Nrf2 is master regulator of an adaptive cytoprotective stress response program, which includes nearly all cellular antioxidant genes involving in inhibition of oxidative stress. Pharmacological activators of Nrf2 are shown to protect from or mitigate progression of various chronic diseases. Diverse classes of phytochemical such as polyphenol, triterpenoid, isothiocyanate or flavonoid are shown to be potent activators of Nrf2 pathway.
Pages: 61-64  |  94 Views  16 Downloads
How to cite this article:
Rashmi KS, Shashikala MD. Role of medicinal plants on inflammatory diseases: A review. Int J Herb Med 2021;9(3):61-64.
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International Journal of Herbal Medicine