Author(s): Eli Kassis and Poul Aage Hansen

Abstract: A blend of herbal extracts (Weighlevel® One; a mixture of extracts from the leaves of Alchemilla vulgaris, Olea europaea, Mentha longifolia and from the seeds of Cuminum cyminum) taken once per day has previously been shown to be effective in producing weight loss in healthy volunteers. The aim of the present study was to confirm if the effects previously observed are reproducible in a second cohort of healthy volunteers. Thirty adult subjects were randomized to consume the herbal blend (n = 15) or placebo (n = 15) once per day for 8 weeks. Weight and waist circumference were assessed weekly. The primary endpoint was the change from baseline in body weight for the herbal blend group compared with placebo. Secondary assessments included waist circumference, appetite, craving, bowel health, and safety and tolerability. Treatment with the herbal blend for 8 weeks produced progressive and significant reductions in weight. Corresponding statistically significant reductions in body mass index and waist circumference were also observed. Weight loss with this herbal extract was similar to that observed in previous studies thus demonstrating a reproducible effect. Daily administration of this blend of herbal extracts supports weight loss.