Author(s): Dr. CS Janaki and Dr. Damodar C Reddy

Abstract: Hypertension (HTN) prevalence in India now estimated at 29.8%. HTN accounts for 57% of all stroke deaths and 24% of all coronary heart disease (CHD) deaths in India. The present study aims to determine the effect of a multi-component water extract on systolic and diastolic blood pressure levels in hypertensive subjects and corresponding lowering of cardio vascular risk factors. The components of the herbal water extract were Black Cumin, Cinnamon, Turmeric, Ginger, Cardamom, Nutmeg, Clove, Guava Leaves, Flax Seeds, Cumin, Fenugreek, Fennel Seeds, and Licorice. A single-center, prospective, open-labeled, non-interventional, observational study was performed with 50 hypertensive subjects for 180 days. Five visits with intermediary evaluations on the 30th and 90th day were carried out. The systolic and diastolic blood pressure, C-reactive protein (CRP), HbA1c were monitored. Significant and gradual decrease (average of 48 mm Hg) in systolic blood pressure (SBP), a decrease (average of 34 mm Hg) in diastolic blood pressure (DBP), and a reduction (average of 9.1%) in C-reactive protein (CRP) were observed after 180 days. All 50 subjects in the study have shown reduction in SBP and DBP with minimum reduction of 29 mm Hg and 17 mm Hg by day 180 versus baseline values respectively. The findings are independent of their medication/s profile with anti-hypertensive drugs. The herbal extract is effective in reducing the SBP and DBP of all the subjects when administrated as an adjuvant therapy.