Author(s): Kris Herawan Timotius, Anthony Tjajaindra and Susana Elya Sudradjat

Abstract: Physalis angulata is a medicinal plant known for its anti-inflammatory potential. It is used traditionally in the therapy of various inflammation-related diseases. This review aimed to compile information on the anti-inflammatory bioactive compounds from Physalis angulata, and their anti-inflammatory mechanisms. Relevant literatures were searched from PubMed and Science Direct. Potential anti-inflammatory bioactive compounds of Physalis angulata are phytosterols and non-steroid compounds. The unique phytosterol compounds are Physalins and Withanolides. The non-steroid bioactive compounds are Quercetin, Ursolic acid, Lupeol and Emodin. The anti-inflammation mechanisms are inhibition of macrophage activation, nuclear factor-kappa beta (NF-κB), myeloperoxidase, cyclooxygenase, inducible nitrite oxide synthase, proinflammatory cytokines, monocytes chemoattractant protein-1, and anti-inflammatory cytokines. For therapeutic purposes, extracts of Physalis angulata can be administrated as single or adjuvant agent of inflammation-related diseases in several organ systems. Aqueous extract can be consumed orally as herbal drink. Ethanolic or methanolic extracts are available as capsule or cream formula. Various parts of Physalis angulata are source of herbal medicine in the treatment of inflammation-related diseases.