Vol. 10, Issue 1, Part A (2022)
Diuretic and antioxidant activities of aqueous stems and leaves extracts of Sida veronicaefolia (lam), Nelsonia canescens (lam) spreng and Crassocephalum bauchiense (hutch.) Milne–redh on female wistar rats
Author(s): DM Yemele, SN Djina, LL Lienou, N Kodjo, RS Tagne, MV Tsague, PB Telefo and PF Moundipa
The objective was to study the diuretic and antioxidant activities of aqueous extract of stems and leaves of Sida veronicaefolia (AESLSV), Nelsonia canescens (ASLENC) and Crassocephalum bauchiense (AESLCB) 14 groups of female rats were used to study the diuretic activity of extracts. Groups I and II serves as controls (and other Groups received different doses of plants extracts. y after the treatment, all the rats were placed in to the metabolic cages for rat urines collection. Finally, different urinary parameters were measured. The antioxidant activities were carried out by the DPPH and FRAP tests.
The AESLSV, AESLNC and AESLCB at different doses have significantly increased the percentage of urinary excretion and urinary excretion levels of electrolytes. A dose dependent decrease of the aldosterone index was observed in animals treated with different doses of AESLNC and AESLCB. Since other index evaluated did not change, the AESLSV would act as a loop diuretic while the two other extracts would act as thiazides.
At the end of the DPPH reduction test, he IC50 of different extracts were 204.17; 29.36 and 35.30 µg/ml respectively for AESLSV, AESLNC and AESLCB. The FRAP of ours extracts was low compared to those vitamin C. This means that AESLSV have low in vitro antioxidant potential while AESLNC and AESLCB have moderate potential.
The results obtained show that the different plant extracts possess diuretic and anti-oxydant activities. Consequently, their use as diuretic is justified.
How to cite this article:
DM Yemele, SN Djina, LL Lienou, N Kodjo, RS Tagne, MV Tsague, PB Telefo, PF Moundipa. Diuretic and antioxidant activities of aqueous stems and leaves extracts of Sida veronicaefolia (lam), Nelsonia canescens (lam) spreng and Crassocephalum bauchiense (hutch.) Milne–redh on female wistar rats. Int J Herb Med 2022;10(1):40-47.