The current study focused on the documentation, analysis, and interpretation of ethnomedicinal phyto-wisdom in the Seraj valley of Himachal Pradesh's Mandi region. The poor tribal and rural population of Seraj valley, Mandi district, Himachal Pradesh, India, do not have access to adequate primary healthcare. They have long used medicinal plants found in their surroundings for a variety of purposes, including therapeutic purposes. The goal of this study was to document ethnobotanical knowledge, especially of notable herbs used by various backward populations in the study area, whether tribal or rural. Structured interviews and conversations with tri-bal/rural informants, healers, medicine-men/women, and others aged 40-70 were used to obtain ethnomedical data. For each claim, a minimum of five to eight sources were considered. This survey discovered that residents of the study area Seraj commonly use about 50 plant species from numerous different families. The most widely used plant components include leaves, flowers, fruit, stem bark, and root. People in Seraj, Mandi district, use native medicinal herbs to cure a wide range of ailments. These ethnomedicinal claims could contribute in the discovery of new treatments.