Atopic dermatitis is an inflammatory dermatosis whose consequences (morbidity and patient quality of life) make it a public health burden. The present study aimed to evalute the in vivo effect of aqueous and ethanolic extracts of S. camptoneura (Loganiaceae) seeds on a model of dermatitis in mice. Dermatitis was induced by application of 25 μl of oxazolone 7 days after sensibilization and the extracts effect estimated by measuring the variations in the thicknesses of edematous ears of the treated animals compared to the thicknesses before induction, and the control group. The extracts action was elucidated by the variation of the MPO and ALKP activities. The results revealed a significant (*p<0.05; **p<0.01) inhibition of oedema with aqueous, ethanol extracts and hydrocortisone 0.1% respectively compared to the control. A non-significant decrease (*p>0.05) of MPO activity with the aqueous extract against significant decrease (*p<0.05; **p<0.01)) with ethanolic extract and hydrocortisone respectively; non-significant decrease (*p>0.05) of ALKP activity with the aqueous and ethanolic extracts whereas it is significant (*p<0.05) with hydrocortisone 0.1% compared to the control. These results show that the extracts of S. camptoneura seeds endowed anti-inflammatory potentialities and act in inflammation like hydrocortisone cream by inhibiting the production of inflammation enzymes.