Musculoskeletal injuries are most common risk factors for sport persons. Pain and swelling are the most common associated symptoms of such injuries. A use of non-steroidal anti-inflammatory drugs (NSAIDs) has been routine in the management of musculoskeletal inflammation and pain. Although effective at reducing pain and inflammation, NSAIDs may not be appropriate to use frequently or longer time due to their known side effects. Herbal and Ayurveda products are widely perceived as safe due to their natural origin and long historical clinical use. Hence in the present study, different quality control parameters for raw material and finished product (polyherbal pain reliever cream) were evaluated like Acid value, Saponification Value, Free fatty acid determination, Viscosity, Specific gravity, Refractive index, Moisture content, Analysis of heavy metals performed. Finger printing profile for the Oils which includes raw ingredients & finish products both. All data from results suggest that cream and its composition were consistent with various quality and purity parameters such as organoleptic characters, physicochemical parameter, fingerprinting analysis, Quantification of methanol in formulation, Heavy metal analysis and Microbial analysis.