Author(s): Jalal Fandi, Ailsi Sami Alhames, Farah Waled Hamed and Dr. Bassel Hussein

Abstract: The skin is the largest organ in the human body which is affected by many diseases. Acne vulgaris (AV) is a multifactorial inflammatory disorder affecting skin areas, and the patients constitute a large proportion of dermatology clinics worldwide. The most severe occurrence is during adolescence, a self-extension disease with psychological side and physical effects. This study aimed to prepare a pharmaceutical dosage form (Dermic cream), apply it to AV patients, and evaluate its efficacy and safety. The prepared cream contained an alcoholic extract of two widespread leafy vegetables: Cabbage and Lettuce. After applying the exclusion parameters on 34 volunteers, only 19 patients were chosen, and they applied the cream for 30 days twice a day. The results showed different responses to the treatment. The severe and moderate cases of AV had reduced to mild cases, and the mild cases were utterly healed after applying the cream for nearly 15 days. This study proved the efficacy of both cabbage and lettuce in a dermal cream for the treatment of acne. The best concentration of cabbage was 6%, and it gave an anti-inflammatory effect, while the best concentration of lettuce was 2% which had a peeling effect. This study also found that the prepared cream was well-tolerated and had minimal side effects. These findings suggest that cabbage and lettuce extracts could be together a safe and effective natural alternative for treating acne vulgaris.

DOI: 10.22271/flora.2023.v11.i4a.879