Vitamin C is a vital circulating antioxidant with anti-inflammatory and immune-boosting properties that are required for good health throughout the life cycle. The coronavirus disease (SARSCov-2) pandemic is now being done; every doctor has suggested consuming vitamin C as a dietary supplement. Besides an extensive range of significances, we want to focus the vit C-rich natural resources despite costly drugs and supplements. we have taken 6 different types of citrus fruits; Citrus aurantifolia or C. limon, the aroma king lemon, Citrus limetta, Citrus reticulata, Citrus sinensis, and Citrus maxima all of these are easily available in the market and affordable too. For every financial class in our country. This paper has shed light on comparative nutritional analysis, the mechanism of their vitro cell viability, anthelmintic, and antibacterial activity of these fruits and indigenous. Interestingly. Maxima contain (0.972±0.002 mg/ounce) 99.89 % vitamin C in comparison to the limcee tab. amount significant amount of protein is present in C. limetta 138.49±4.003 mg BSAE/ml. Citrus limon shows good antimicrobial activity, C. reticulata and C. sinensis show potentiality about death time and paralysis time of helminths. Ascorbic acid helps in the enhanced survival of macrophages which are the body’s first line of defence. Using the current level of knowledge this paper is attracting the focus of healthcare practitioners, who will give suggestions for having different kinds of lemons that will boost the immunity of the community.