Author(s): Shaikh A, Bhandirge S, Khan A and Gawande A

Abstract: Due to damage of Hepatic tissue, there may impairment in liver function which may have deleterious effect on human health. Management of liver diseases by using natural herb is recent need. In this research we evaluated the hepatoprotective activity of ethanolic extract of SBBM against TTA induced hepatotoxicity in rats. (Group I received 0.1% CMC, Group II received only TTA, Group III received sily marin, Group IV received ethanolic extract of SBBM orally 200 mg/kg &Group V received ethanolic extract of SBBM orally 400 mg/kg)Group II-V received intraperitonial injection of TAA. On 16th day of the experimental period, animals were sacrificed, the serum was separated for the estimations of histopathalogical, biochemical& morphological parameters, results suggest that it may contribute to the chemopreventive effect of SBBM showed a significant recovery in the level of glutathione and its metabolizing enzyme in the liver, which is shown by the elevated levels of SGOT, SGPT, GSH and Lipid peroxidation, Hence, on the basis of result obtained it can be said that SBBM exercised powerful free radical scavenging activity and hepatoprotective activity.