Author(s): Roshni Ghosh, Sirshendu Chatterjee and Moumita Saha

Abstract: Cancer is considered a fatal disease across the globe, irrespective of the economic or social condition of any country. Therefore, the search for its effective cure is one of the most crucial tasks for humankind. Even after extensive research, many patients around the world still face the adversities of this incurable malady. According to ancient and modern-day innovations, all curative herbs are believed to have anti-carcinomic plant chemicals which can be used in the natural treatment of cancer. The curability of these plant chemicals was tested on a sizeable number of patients, which therefore doesn’t help in gathering significant data on their proficiency. This review study was conducted on the prolonged benefits and their protective abilities to cure cancer of plant chemicals obtained from Hibiscus rosa-sinensis (Shoeblack plant), Calendula officinalis (Pot marigold), Tabernaemontana divaricata (crape jasmine), and Catharanthus Roseus (Madagascar periwinkle). These plants control the articulation of metabolism-related protein and oxidative stress thereby improving metabolism. Additionally, A handful of plant compounds are said to have a positive influence on a range of cancer-associated symptoms. Vinca alkaloids in Catharanthus Roseus activate apoptosis in carcinomic cells by restricting the gathering of microtubule structures and obstructing mitosis in the metaphase. Also, C. officinalis exhibits anti-carcinomic outcomes by complex signaling pathways, influencing cell propagation, programmed cell death, cell cycle development, and metastasis, resulting in being an important resource for carcinoma research. Likewise, T. divaricate shows optimistic results as an origin for a carcinoma-preventing drug. Alkaloids obtained from the shrub exhibit numerous cancer inhibitory and anti-carcinomic effects, paving the way to the cytotoxic invention. T. divaricate is rich in alkaloid content. Furthermore, the flavonoids in Hibiscus rosa-sinensis show optimistic results in combating carcinoma by aiming at fundamental cellular pathways, comprising, NF-κβ, EGFR/MAPK, PI3K/Akt, thus repressing carcinomic cell propagation. However, scant evidence shows that there is not enough resource to reinforce the efficacy of these drugs in combating cancer.

DOI: 10.22271/flora.2024.v12.i1a.914