International Journal of Herbal Medicine
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P-ISSN: 2394-0514, E-ISSN: 2321-2187   |   Impact Factor: RJIF 5.20
International Journal of Herbal Medicine
Vol. 12, Issue 2, Part A (2024)

VIROSCOPE®, an ethanolic extract of medicinal plants produced in Lomé, Togo, demonstrated excellent anti-inflammatory and immune cell proliferation activities

Author(s): Komla Mawunyo Dossouvi, Kossi Jean Dossouvi, Akueba Landrine Dossouvi and Kokou Dossouvi
Abstract: The World Health Organization (WHO) estimated that at least 80% of the world's population finds its main, if not exclusive, therapeutic source in plants. Inflammation and associated diseases have been reported to be a great threat to public health, as evidenced by the deadly cytokine storms observed during the latest COVID-19 pandemic. Several phytomedicines with excellent anti-inflammatory and immunostimulatory activities have been reported worldwide. Thus, this study evaluated the in vitro cytotoxicity, immune cell proliferation and immunosuppressive activities of a phytomedicine “VIROSCOPE®” produced by Viroscope SARL-U in Lomé, Togo. Cytotoxicity was assessed using the Propidium Iodide Membrane Integrity Test and interpreted according to NF EN ISO 10993-5. The immune cell proliferation property was assessed by evaluating the expression of the proliferating cell nuclear antigen (PCNA) in white blood cells by flow cytometry. Evaluation of IL-6 and TNF α production by Sandwich ELISA was used to evaluate the immunosuppressive and immunostimulatory properties of VIROSCOPE®. VIROSCOPE® demonstrated slight and mild cytotoxicity, depending on the dose. In addition, VIROSCOPE® induced excellent in vitro immune cell proliferation and showed excellent anti-inflammatory activity. All these immunomodulatory activities were dose-dependent, calling for strict compliance with the dosage. Further in vitro studies, animal model tests, and clinical trials are needed to elucidate all the therapeutic activities of VIROSCOPE® and to improve its formulation.
Pages: 10-15  |  128 Views  75 Downloads


International Journal of Herbal Medicine
How to cite this article:
Komla Mawunyo Dossouvi, Kossi Jean Dossouvi, Akueba Landrine Dossouvi, Kokou Dossouvi. VIROSCOPE®, an ethanolic extract of medicinal plants produced in Lomé, Togo, demonstrated excellent anti-inflammatory and immune cell proliferation activities. Int J Herb Med 2024;12(2):10-15. DOI: 10.22271/flora.2024.v12.i2a.925

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