Author(s): Khushboo Vaghela, Divya Mahyavanshi, Vidhi Jethva, Ankit Modi, Mansi Kaushal and Divyakant Patel

Abstract: One of the most prevalent gastrointestinal (GI) issues of our time, gastric ulcers (GUs) are open sores that form on the inside of the stomach's mucosal lining and affect about 10% of the global population. Due to the breakdown of the equilibrium between the gastric mucosa's natural defence mechanism, aggressive factors (Such as the secretion of gastric acid and pepsin, oxidants, free radicals, leukotrienes, and endothelin), and exogenous factors (such as Helicobacter pylori infection, alcohol use, and non-steroidal anti-inflammatory drugs), the disorder is multifactorial and complex. Nowadays, H2 antihistamines, proto-pump inhibitors, ulcer protectants, and antiulcer medications are used to treat and prevent GUs. Extended usage of these chemicals is frequently linked to problems such as diarrhoea, anaemia, and enterochromaffin-like (ECL) cell hyperplasia. Herbal remedies have been used since ancient times to treat a variety of disorders like gastro-protective and anti-ulcer activities. So for the treatment of anti-ulcer activity various herbs are used for treatment like Triphala powder (Amla, Harde, Baheda), pumpkin seed, black cumin seeds, fennel fruit, black raisin, fenugreek seeds all having the gastro-intestinal protective action and also soothes the mucosal lining of the stomach.

DOI: 10.22271/flora.2024.v12.i5a.949