Author(s): Zeeshan A Pinjari, Jayesh D Patil, Sushant R Panpatil, Niraj S Pawar Hemant P Suryawanshi and RA Ahirrao

Abstract: Helminthic infections are still a major public health problem, especially among developing nations. As resistance and safety issues of synthetic anthelmintics have been on the rise, it has become important to search for plant-based alternatives. In this paper, the in vitro anthelmintic activity of aqueous and ethanolic leaf extracts of Clerodendrum phlomidis L. F. Was assessed using Pheretima posthuma as the test organism. Extracts were macerated and tested between 25 to 100 mg/ml concentrations. Albendazole (10 mg/ml) was used as the control, and normal saline as the standard. The ethanolic extract was more potent than the aqueous extract, causing paralysis and mortality at 12.36 and 69.20 minutes, respectively, at the highest concentration. One-way ANOVA with subsequent Tukey’s HSD test indicated statistically significant variation between all groups (p < 0.001). Albendazole proved to be most effective, whereas the control was inactive. Results substantiate the traditional application of C. phlomidis as an anthelmintic and indicate its promise for additional pharmacological and phytochemical research.

DOI: 10.22271/flora.2025.v13.i6a.1038