Author(s): S Bhagavathy and Sirisha Kancharla

Abstract: Nanomaterials are potential to treat the human diseases HIV, malaria, TB, diabetes and cardiac problems. The present work was aimed to detect the wound healing and angiogenesis of silver nanoparticles (SNP) extracted from Azadirachta indica (A. indica). 20g of A. indica Leaf contains 20mg of SNP. SEM and XRD analysis showed the size and characterization of the silver particle was less than 100nm. Thermal wound induced in diabetes animals model was used for wound healing effects of SNP. The wounds decreased in size gradually with time, closed at 2 weeks in normal mice and at 3 weeks in diabetic mice. In diabetic mice at 15 days, a significant difference in (P<0.01) wound closure was noted on the skin. Histopathological observation of skin showed improvement in the surface epithelium. The results of the present study revealed that the SNP from A. indica considered as a potential drug target for tissue injury.